| Weight | 574.354 g/mol |
|---|---|
| Formula | C24H34Br2N2O4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 3 |
Hemicholinium-3 (312-45-8)
Hemicholinium · Hemicholinium 3
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#1122 in Neuroscience
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#4864 in Biology
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#6216 in Chemistry
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- Attentional functions of the forebrain cholinergic systems: effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task (Experimental Brain Research, 1992)
- Inhibition by hemicholinium-3 of (14C)acetylcholine synthesis and (3H)choline high-affinity uptake in rat striatal synaptosomes. (Molecular Pharmacology, 1973)
- Presynaptic action of hemicholinium at the neuromuscular junction (The Journal of Physiology, 1965)
- Molecular cloning of a human, hemicholinium-3-sensitive choline transporter. (Biochemical and Biophysical Research Communications, 2000)
- The effects of nerve stimulation and hemicholinium on synaptic vesicles at the mammalian neuromuscular junction (The Journal of Physiology, 1970)
- The inhibition of acetylcholine synthesis in brain by a hemicholinium. (Biochemical Journal, 1961)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Hemicholinium
- Hemicholinium 3
-
SMILESC[N+]1(CCOC(C1)(C2=CC=C(C=C2)C3=CC=C(C=C3)C4(C[N+](CCO4)(C)C)O)O)C.[Br-].[Br-]
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InChIKeyOPYKHUMNFAMIBL-UHFFFAOYSA-L
- Pubchem - Hemicholinium-3
- Wikipedia - Hemicholinium-3
Hemicholinium-3 (HC3), also known as hemicholine, is a drug which blocks the reuptake of choline by the high-affinity choline transporter (ChT; encoded in humans by the gene SLC5A7) at the presynapse. The reuptake of choline is the rate limiting step in the synthesis of acetylcholine; hence, hemicholinium-3 decreases the synthesis of acetylcholine. It is therefore classified as an indirect acetylcholine antagonist.
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Hemicholinium-3
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