| Weight | 287.315 g/mol |
|---|---|
| Formula | C16H17NO4 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 0 |
lycorine (2188-68-3, 476-28-8)
lycorine hydrochloride, (1alpha,2beta)-isomer · 2,4,5,7,12b,12c-hexahydro-1H-(1,3)dioxolo- (4,5-j)pyrrolo(3,2,1-de)phenanthridine-1,2-diol
Score:
#2332 in Biochemistry
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#4635 in Biology
,
#5881 in Chemistry
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- Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight. (Journal of Medicinal Chemistry, 2009)
- Disposable electrochemical biosensor for the detection of the interaction between DNA and lycorine based on guanine and adenine signals (Journal of Pharmaceutical and Biomedical Analysis, 2003)
- Effects of lycorine on HL60 cells via arresting cell cycle and inducing apoptosis (FEBS Letters, 2004)
- The amaryllidaceae alkaloids : Absolute configurations of diastereoisomeric methiodides in the lycorine-type alkaloids (Tetrahedron, 1968)
- Lycorine as an inhibitor of ascorbic acid biosynthesis (Nature, 1975)
- Lycorine induces apoptosis and down-regulation of Mcl-1 in human leukemia cells (Cancer Letters, 2009)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - lycorine hydrochloride, (1alpha,2beta)-isomer
- 2,4,5,7,12b,12c-hexahydro-1H-(1,3)dioxolo- (4,5-j)pyrrolo(3,2,1-de)phenanthridine-1,2-diol
-
SMILESC1CN2CC3=CC4=C(C=C3C5C2C1=CC(C5O)O)OCO4
-
InChIKeyXGVJWXAYKUHDOO-UHFFFAOYSA-N
- Pubchem - lycorine
- Wikipedia - lycorine
Lycorine is a toxic crystalline alkaloid found in various Amaryllidaceae species, such as the cultivated bush lily (Clivia miniata), surprise lilies (Lycoris), and daffodils (Narcissus). It may be highly poisonous, or even lethal, when ingested in certain quantities. Regardless, it is sometimes used medicinally, a reason why some groups may harvest the very popular Clivia miniata.
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