| Weight | 454.913 g/mol |
|---|---|
| Formula | C18H15ClN2O6S2 |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 6 |
Sitaxsentan (184036-34-8, 210421-64-0)
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- Sigma-Aldrich - Sitaxsentan150.00 USD
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- Sitaxsentan Therapy for Pulmonary Arterial Hypertension (American Journal of Respiratory and Critical Care Medicine, 2004)
- Treatment of Pulmonary Arterial Hypertension With the Selective Endothelin-A Receptor Antagonist Sitaxsentan (Journal of the American College of Cardiology, 2006)
- Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension: open-label pilot study. (Chest, 2002)
- Ambrisentan Therapy in Patients With Pulmonary Arterial Hypertension Who Discontinued Bosentan or Sitaxsentan Due to Liver Function Test Abnormalities (Chest, 2006)
- Sitaxsentan for the Treatment of Pulmonary Arterial Hypertension: A 1-Year, Prospective, Open-Label Observation of Outcome and Survival (Chest, 2008)
- Selective endothelinA receptor antagonism with sitaxsentan for pulmonary arterial hypertension associated with connective tissue disease (Annals of the Rheumatic Diseases, 2007)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=CC2=C(C=C1CC(=O)C3=C(C=CS3)S(=O)(=O)NC4=C(C(=NO4)C)Cl)OCO2
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InChIKeyPHWXUGHIIBDVKD-UHFFFAOYSA-N
- Pubchem - Sitaxsentan
- Wikipedia - sitaxentan
Sitaxentan sodium (TBC-11251) is a medication for the treatment of pulmonary arterial hypertension (PAH). It was marketed as Thelin by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008. In 2010, Pfizer voluntarily removed sitaxentan from the market due to concerns about liver toxicity.
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