Weight | 425.4 g/mol |
---|---|
Formula | C22H30Cl2N2O2 |
Hydrogen Acceptors | 3 |
Hydrogen Donors | 0 |
Aromatic Rings | 1 |
Rotatable Bonds | 4 |
SPIRADOLINE (87151-85-7)
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- Analgesic and mechanistic evaluation of spiradoline, a potent kappa opioid. (Journal of Pharmacology and Experimental Therapeutics, 1988)
- A Review of the Properties of Spiradoline: A Potent and Selective kOpioid Receptor Agonist (Cns Drug Reviews, 2006)
- The effects of spiradoline (U-62066E), a -opioid receptor agonist, on neuroendocrine function in man (British Journal of Pharmacology, 1997)
- Neuroendocrine and behavioral effects of the selective kappa agonist spiradoline in Tourette's syndrome: A pilot study (Psychiatry Research-neuroimaging, 1993)
- Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats. (Pharmacology, Biochemistry and Behavior, 2009)
- Discriminative stimulus effects of spiradoline, a kappa-opioid agonist (Psychopharmacology, 1991)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCN(C1CCC2(CCCO2)CC1N3CCCC3)C(=O)CC4=CC(=C(C=C4)Cl)Cl
-
InChIKeyNYKCGQQJNVPOLU-UHFFFAOYSA-N
- Pubchem - SPIRADOLINE
- Wikipedia - spiradoline
Spiradoline (U-62066) is a drug which acts as a highly selective -opioid agonist. It has analgesic, diuretic and antitussive effects, and produces subjective effects in animals similar to those of ketazocine and alazocine. The main effect in humans is sedation, along with analgesic and diuretic effects, but significant side effects such as dysphoria and hallucinations have stopped it from being used clinically.
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SCHEMBL10987057
(Schotten-Baumann amide from acid)
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