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Most-cited Publications

• Trilostane, an orally active inhibitor of steroid biosynthesis. (Steroids, 1978)
• Trilostane treatment of 78 dogs with pituitary-dependent hyperadrenocorticism (Veterinary Record, 2002)
• Treatment of Cushing's Syndrome with Trilostane (WIN 24,540), an Inhibitor of Adrenal Steroid Biosynthesis* (The Journal of Clinical Endocrinology and Metabolism, 1978)
• Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane (American Journal of Veterinary Research, 2002)
• Trilostane treatment in dogs with pituitary-dependent hyperadreno-corticism (Australian Veterinary Journal, 2003)
• Long-term efficacy of trilostane administered twice daily in dogs with pituitary-dependent hyperadrenocorticism. (Journal of The American Animal Hospital Association, 2006)

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Trends

Alternate Names

• 4alpha,5-epoxy-17beta-hydroxy-3-oxoandrostane-2-carbonitrile
• Modrenal
• WIN 24,540
• SMILES
  CC12CCC3C(C1CCC2O)CCC45C3(CC(=C(C4O5)O)C#N)C
• InChIKey
  KVJXBPDAXMEYOA-UHFFFAOYSA-N

External Links

• Pubchem - Trilostane
• Wikipedia - trilostane
  Trilostane is a steroidogenesis inhibitor which is used in the treatment of Cushing's syndrome. It was withdrawn from human use in the United States market in April 1994. The drug was previously available in the United Kingdom for use in humans under the brand name Modrenal for the treatment of Cushing's disease and for breast cancer.

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