| Weight | 584.838 g/mol |
|---|---|
| Formula | C36H56O6 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 6 |
Bevirimat (174022-42-5)
Score:
#17 in Medicinal chemistry
,
#17 in Virology
,
#437 in Microbiology
,
#3505 in Biology
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- Phase I and II Study of the Safety, Virologic Effect, and Pharmacokinetics/Pharmacodynamics of Single-Dose 3-O-(3,3-Dimethylsuccinyl)Betulinic Acid (Bevirimat) against Human Immunodeficiency Virus Infection (Antimicrobial Agents and Chemotherapy, 2007)
- In Vitro Resistance to the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PA-457 (Bevirimat) (Journal of Virology, 2006)
- HIV-1 Maturation Inhibitor Bevirimat Stabilizes the Immature Gag Lattice (Journal of Virology, 2011)
- Safety and Pharmacokinetics of Bevirimat (PA-457), a Novel Inhibitor of Human Immunodeficiency Virus Maturation, in Healthy Volunteers (Antimicrobial Agents and Chemotherapy, 2007)
- Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1maturation inhibitor bevirimat (Retrovirology, 2010)
- Susceptibility of Human Immunodeficiency Virus Type 1 to the Maturation Inhibitor Bevirimat Is Modulated by Baseline Polymorphisms in Gag Spacer Peptide 1 (Antimicrobial Agents and Chemotherapy, 2009)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)OC(=O)CC(C)(C)C(=O)O)C)C(=O)O
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- Pubchem - Bevirimat
- Wikipedia - bevirimat
Bevirimat (research code MPC-4326) is an anti-HIV drug derived from a betulinic acid-like compound, first isolated from Syzygium claviflorum, a Chinese herb. It is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition. It is not currently U.S.
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