| Weight | 384.586 g/mol |
|---|---|
| Formula | C20H36N2O3S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 14 |
Ibutilide (122647-32-9, 122647-31-8)
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- Efficacy and Safety of Repeated Intravenous Doses of Ibutilide for Rapid Conversion of Atrial Flutter or Fibrillation (Circulation, 1996)
- Facilitating transthoracic cardioversion of atrial fibrillation with ibutilide pretreatment (The New England Journal of Medicine, 1999)
- Efficacy of intravenous ibutilide for rapid termination of atrial fibrillation and atrial flutter: A dose-response study (Journal of the American College of Cardiology, 1996)
- Frequency Analysis of Human Atrial Fibrillation Using the Surface Electrocardiogram and Its Response to Ibutilide (American Journal of Cardiology, 1998)
- Conversion efficacy and safety of intravenous ibutilide compared with intravenous procainamide in patients with atrial flutter or fibrillation (Journal of the American College of Cardiology, 1998)
- Efficacy and Safety of Ibutilide Fumarate for the Conversion of Atrial Arrhythmias After Cardiac Surgery (Circulation, 1999)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O
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InChIKeyALOBUEHUHMBRLE-UHFFFAOYSA-N
- Pubchem - Ibutilide
- Wikipedia - ibutilide
Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells. Because of its Class III antiarrhythmic activity, there should not be concomitant administration of Class Ia and Class III agents.
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Synthesis
Reactant
+
N-(4-chlorophenyl)methanesulfonamide
(Grignard alcohol)
Methanesulfonyl chloride
+
Reactant
(Sulfonamide)
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