Weight | 473.446 g/mol |
---|---|
Formula | C20H23N7O7 |
Hydrogen Acceptors | 9 |
Hydrogen Donors | 7 |
Aromatic Rings | 2 |
Rotatable Bonds | 10 |
Levoleucovorin
6 S leucovorin · 6S leucovorin · Leucovorin, Monopotassium Salt, (S)-Isomer
58-05-9, 68538-85-2, 1492-18-8
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- Sigma-Aldrich - Search for Levoleucovorin
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Most-cited Publications
- Intensive weekly chemotherapy for advanced gastric cancer using fluorouracil, cisplatin, epi-doxorubicin, 6S-leucovorin, glutathione, and filgrastim: a report from the Italian Group for the Study of Digestive Tract Cancer. (Journal of Clinical Oncology, 1997)
- High curative resection rate with weekly cisplatin, 5-fluorouracil, epidoxorubicin, 6S-leucovorin, glutathione, and filgastrim in patients with locally advanced, unresectable gastric cancer: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD) (British Journal of Cancer, 2004)
- Biweekly irinotecan or raltitrexed plus 6S-leucovorin and bolus 5-fluorouracil in advanced colorectal carcinoma: A Southern Italy Cooperative Oncology Group phase IIIII randomized trial (Annals of Oncology, 2000)
- Intensive weekly chemotherapy for locally advanced gastric cancer using 5-fluorouracil, cisplatin, epidoxorubicin, 6S-leucovorin, glutathione and filgrastim: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD). (British Journal of Cancer, 1998)
- A phase II study of weekly cisplatin, 6S-stereoisomer leucovorin and fluorouracil as first-line chemotherapy for elderly patients with advanced gastric cancer (British Journal of Cancer, 2003)
- Interactions of carboxypeptidase G2 with 6S-leucovorin and 6R-leucovorin in vitro: implications for the application in case of methotrexate intoxications (Cancer Chemotherapy and Pharmacology, 2005)
Safety
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more.
Trends
Alternate Names
- 6 S leucovorin
- 6S leucovorin
- Leucovorin, Monopotassium Salt, (S)-Isomer
- Fusilev
- S-leucovorin
- Leucovorin, Calcium (1:1) Salt, (S)-Isomer
- 6S-leucovorin
- (6S)-leucovorin
- Leucovorin, (S)-Isomer
- levo leucovorin
- Leucovorin, Monosodium Salt, (S)-Isomer
- 6-S-leucovorin
- levo-leucovorin
- S leucovorin
-
SMILESC1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
-
InChIKeyVVIAGPKUTFNRDU-UHFFFAOYSA-N
External Links
- Pubchem - Levoleucovorin
- Wikipedia - levoleucovorin
Levoleucovorin is the enantiomerically active form of Folinic acid. A study from authors at Georgetown University have shown that there is no safety or efficacy benefit to levoleucovorin.
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