| Weight | 290.198 g/mol |
|---|---|
| Formula | C11H17Cl2N5 |
| Hydrogen Acceptors | 1 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 2 |
Proguanil hydrochloride (637-32-1)
Proguanil · Paludrine · Chloroguanide
Score:
#407 in Microbiology
,
#3225 in Biology
,
#4034 in Chemistry
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- Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. (American Journal of Tropical Medicine and Hygiene, 1995)
- Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil (Proceedings of the National Academy of Sciences of the United States of America, 1997)
- Acquired resistance to proguanil in Plasmodium vivax. (The Lancet, 1949)
- Atovaquone-Proguanil versus Mefloquine for Malaria Prophylaxis in Nonimmune Travelers: Results from a Randomized, Double-Blind Study (Clinical Infectious Diseases, 2001)
- A Mechanism for the Synergistic Antimalarial Action of Atovaquone and Proguanil (Antimicrobial Agents and Chemotherapy, 1999)
- Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group. (American Journal of Tropical Medicine and Hygiene, 1999)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Proguanil
- Paludrine
- Chloroguanide
- Chloroguanide Hydrochloride
- Bigumal
- Chloriguane
- Paludrin
- Chlorguanid
-
SMILESCC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl.Cl
-
InChIKeySARMGXPVOFNNNG-UHFFFAOYSA-N
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N'-Propan-2-ylmethanediimine
+
Reactant
(Thiourea)
Reactant
+
ISOPROPYLAMINE
(Imine formation from aldehyde)
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Proguanil hydrochloride
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