| Weight | 264.325 g/mol |
|---|---|
| Formula | C14H20N2O3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 6 |
Propacetamol (66532-85-2)
Prodafalgan · N, N-diethylglycine 4'-hydroxyacetanilide ester
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- Efficacy of propacetamol in the treatment of postoperative pain Morphinesparing effect in orthopedic surgery (Acta Anaesthesiologica Scandinavica, 1998)
- Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. (British Journal of Clinical Pharmacology, 1992)
- Pediatric intravenous paracetamol (propacetamol) pharmacokinetics: a population analysis. (Pediatric Anesthesia, 2005)
- The morphine-sparing effect of propacetamol in orthopedic postoperative pain (Journal of Pain and Symptom Management, 1995)
- Intravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery. (Anesthesia & Analgesia, 2001)
- Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use (Fundamental & Clinical Pharmacology, 1992)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Prodafalgan
- N, N-diethylglycine 4'-hydroxyacetanilide ester
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SMILESCCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C
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InChIKeyQTGAJCQTLIRCFL-UHFFFAOYSA-N
- Pubchem - Propacetamol
- Wikipedia - propacetamol
Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by I.V.
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Synthesis
Ethylboronic acid
+
Reactant
(Chan-Lam coupling reaction)
ACETYL CHLORIDE
+
Reactant
(Schotten-Baumann amide from acid)
4-Acetamidobenzaldehyde
+
Reactant
(Dakin oxidation)
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