| Weight | 371.275 g/mol |
|---|---|
| Formula | C16H23BrN2O3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 6 |
Remoxipride (80125-14-0)
Score:
#662 in Neuroscience
,
#2949 in Biology
,
#3691 in Chemistry
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- Remoxipride, a new potential antipsychotic compound with selective anti-dopaminergic actions in the rat brain (European Journal of Pharmacology, 1984)
- A common action of clozapine, haloperidol, and remoxipride on D1- and D2-dopaminergic receptors in the primate cerebral cortex. (Proceedings of the National Academy of Sciences of the United States of America, 1994)
- Clinical profile of remoxipride - a combined analysis of a comparative double-blind multicentre trial programme (Acta Psychiatrica Scandinavica, 1990)
- Effects of Remoxipride and some Related New Substituted Salicylamides on Rat Brain Receptors (Pharmacology & Toxicology, 2009)
- Biochemical pharmacology of the atypical neuroleptic remoxipride. (Acta Psychiatrica Scandinavica, 1990)
- The atypical antipsychotic, remoxipride, blocks phencyclidine-induced disruption of prepulse inhibition in the rat (Psychopharmacology, 1994)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCN1CCCC1CNC(=O)C2=C(C=CC(=C2OC)Br)OC
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InChIKeyGUJRSXAPGDDABA-UHFFFAOYSA-N
- Pubchem - Remoxipride
- Wikipedia - remoxipride
Remoxipride (Roxiam) is an atypical antipsychotic (although according to some sources it is a typical antipsychotic) which was previously used in Europe for the treatment of schizophrenia and acute mania but was withdrawn due to toxicity concerns (incidence of aplastic anemia in 1/10,000 patients). It was initially launched by AstraZeneca in 1990 and suspension of its use began in 1993. Remoxipride acts as a selective D2 and D3 receptor antagonist and also has high affinity for the sigma receptor, possibly playing a role in its atypical neuroleptic action.
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