| Weight | 466.541 g/mol |
|---|---|
| Formula | C28H26N4O3 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 5 |
| Rotatable Bonds | 2 |
staurosporine (62996-74-1)
Score:
#988 in Biochemistry
,
#2596 in Biology
,
#3242 in Chemistry
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- Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase. (Biochemical and Biophysical Research Communications, 1986)
- Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine (Molecular Cell, 2000)
- Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases (Trends in Pharmacological Sciences, 1989)
- SMALL STRESS PROTEINS AS NOVEL REGULATORS OF APOPTOSIS : HEAT SHOCK PROTEIN 27 BLOCKS FAS/APO-1- AND STAUROSPORINE-INDUCED CELL DEATH (Journal of Biological Chemistry, 1996)
- Induction of a Common Pathway of Apoptosis by Staurosporine (Experimental Cell Research, 1994)
- A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. (International Journal of Cancer, 1989)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
-
InChIKeyHKSZLNNOFSGOKW-UHFFFAOYSA-N
- Pubchem - staurosporine
- Wikipedia - staurosporine
Staurosporine (antibiotic AM-2282 or STS) is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. It was the first of over 50 alkaloids to be isolated with this type of bis-indole chemical structure. The chemical structure of staurosporine was elucidated by X-ray analysis of a single crystal and the absolute stereochemical configuration by the same method in 1994.
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