sulpiride (15676-16-1)

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Suppliers

• Sigma-Aldrich - sulpiride
  85.90 - 302.00 USD
• Fisher Scientific - Search for sulpiride
• TCI - Search for sulpiride

Most-cited Publications

• Sulpiride augmentation in people with schizophrenia partially responsive to clozapine. A double-blind, placebo-controlled study. (British Journal of Psychiatry, 1997)
• Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation (Proceedings of the National Academy of Sciences of the United States of America, 2008)
• Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinsons disease (Psychopharmacology, 1999)
• Identification of a SulP-type bicarbonate transporter in marine cyanobacteria (Proceedings of the National Academy of Sciences of the United States of America, 2004)
• The latent inhibition model of schizophrenic attention disorder Haloperidol and sulpiride enhance rats' ability to ignore irrelevant stimuli (Biological Psychiatry, 1991)
• Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers. (Psychopharmacology, 2004)

Areas of Application

Safety

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Trends

Alternate Names

• Sulp
• neogama
• Deponerton
• Sulpitil
• Pontiride
• Sulpivert
• Vertigo-Meresa
• Eglonyl
• Vertigo Meresa
• Psicocen
• Lebopride
• Aiglonyl
• Sulpor
• Syndil
• Ekilid
• Sulperide
• Arminol
• Dogmatil
• vertigo-neogama
• Guastil
• Tepavil
• vertigo neogama
• Digton
• Meresa
• Desisulpid
• Dolmatil
• SMILES
  CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC
• InChIKey
  BGRJTUBHPOOWDU-UHFFFAOYSA-N

External Links

• Pubchem - sulpiride
• Wikipedia - sulpiride
  Sulpiride (brand names Dogmatil ( DE, HK, SG, PH), Dolmatil (IE, UK), Eglonyl (RU, ZA), Espiride (ZA), Modal (IL), Prometar (UY), Sulpor (UK) and others) is an atypical antipsychotic drug (although some texts have referred to it as a typical antipsychotic) of the benzamide class used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression. Sulpiride is commonly used in Asia, Central America, Europe, South Africa and South America. Levosulpiride is its purified levo-isomer and is sold in India for similar purpose.

Synthesis

5-(Aminosulphonyl)-2-methoxybenzoyl chloride  +  2-(Aminomethyl)-1-ethylpyrrolidine (Schotten-Baumann amide from acid)

2-methoxy-5-sulfamoylbenzamide  +  2-(chloromethyl)-1-ethylpyrrolidine (Alkylation of primary amines)

2-methoxy-5-sulfamoylbenzamide  +  Reactant (Amide N-alkylation 2)

Synthesis of sulpiride ›

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