| Weight | 567.796 g/mol |
|---|---|
| Formula | C32H45N3O4S |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 9 |
nelfinavir (159989-64-7)
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#109 in Microbiology
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#1202 in Biology
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#1379 in Chemistry
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- LopinavirRitonavir versus Nelfinavir for the Initial Treatment of HIV Infection (The New England Journal of Medicine, 2002)
- Viracept (Nelfinavir Mesylate, AG1343): A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease (Journal of Medicinal Chemistry, 1997)
- Saquinavir pharmacokinetics alone and in combination with nelfinavir in HIV-infected patients. (AIDS, 1997)
- Pharmacogenetics of Long-Term Responses to Antiretroviral Regimens Containing Efavirenz and/or Nelfinavir: An Adult AIDS Clinical Trials Group Study (The Journal of Infectious Diseases, 2005)
- Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo (Clinical Cancer Research, 2007)
- Incidence of Resistance in a Double-Blind Study Comparing Lopinavir/Ritonavir Plus Stavudine and Lamivudine to Nelfinavir plus Stavudine and Lamivudine (The Journal of Infectious Diseases, 2004)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(CN3CC4CCCCC4CC3C(=O)NC(C)(C)C)O
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InChIKeyQAGYKUNXZHXKMR-UHFFFAOYSA-N
- Pubchem - nelfinavir
- Wikipedia - nelfinavir
Nelfinavir (brand name Viracept) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV). Nelfinavir belongs to the class of drugs known as protease inhibitors (PIs) and like other PIs is almost always used in combination with other antiretroviral drugs. Nelfinavir mesylate (Viracept, formerly AG1343) is a potent and orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor (Ki=2nM) and is widely prescribed in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.
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