| Weight | 482.441 g/mol |
|---|---|
| Formula | C25H22O10 |
| Hydrogen Acceptors | 10 |
| Hydrogen Donors | 5 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 4 |
silibinin (65666-07-1, 22888-70-6)
silybin · Hepatos · Hepar-Pasc
Score:
#1466 in Biochemistry
,
#3461 in Biology
,
#4322 in Chemistry
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- Silybin and silymarin--new and emerging applications in medicine. (Current Medicinal Chemistry, 2007)
- Silybin and silymarin - new effects and applications (2005)
- The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats. (International Journal of Pharmaceutics, 2006)
- Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: Implications for prostate cancer intervention (Proceedings of the National Academy of Sciences of the United States of America, 1999)
- Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin (Hepatology, 1996)
- Silibinin Strongly Synergizes Human Prostate Carcinoma DU145 Cells to Doxorubicin-induced Growth Inhibition, G2-M Arrest, and Apoptosis (Clinical Cancer Research, 2002)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - silybin
- Hepatos
- Hepar-Pasc
- 2,3-dehydrosilybin
- legalon forte
- Heparsyx
- Alepa-forte
- Cefasilymarin
- silibin
- silybinin
- Heplant
- Hepa-Merz Sil
- durasilymarin
- HepaBesch
- hepa-loges
- Ardeyhepan
- Lagosa
-
SMILESCOC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
-
InChIKeySEBFKMXJBCUCAI-UHFFFAOYSA-N
- Pubchem - silibinin
- Wikipedia - silibinin a
Silibinin (INN), also known as silybin (both from Silybum, the generic name of the plant from which it is extracted), is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin, and others. Silibinin itself is a mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio. The mixture exhibits a number of pharmacological effects, particularly in the liver, and there is some clinical evidence for the use of silibinin as a supportive element in alcoholic and child grade 'A' liver cirrhosis.
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