| Weight | 659.641 g/mol |
|---|---|
| Formula | C27H40Cl2N8O5S |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 6 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 8 |
Glucovance (338752-31-1)
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- Improved glycaemic control with metforminglibenclamide combined tablet therapy (Glucovance) in Type 2 diabetic patients inadequately controlled on metformin (Diabetic Medicine, 2002)
- Pharmacokinetics and Pharmacodynamics of Glyburide/Metformin Tablets (Glucovance) versus Equivalent Doses of Glyburide and Metformin in Patients with Type 2 Diabetes (Clinical Pharmacokinectics, 2002)
- Influence of initial hyperglycaemia, weight and age on the blood glucose lowering efficacy and incidence of hypoglycaemic symptoms with a singletablet metforminglibenclamide therapy (Glucovance) in type 2 diabetes (Diabetes, Obesity and Metabolism, 2003)
- Tolerability profile of metformin/glibenclamide combination tablets (Glucovance): a new treatment for the management of type 2 diabetes mellitus. (Drug Safety, 2004)
- Beta-cell response to metformin-glibenclamide combination tablets (Glucovance) in patients with type 2 diabetes. (International Journal of Clinical Practice, 2008)
- Durable efficacy of metformin/glibenclamide combination tablets (Glucovance) during 52 weeks of open-label treatment in type 2 diabetic patients with hyperglycaemia despite previous sulphonylurea monotherapy* (International Journal of Clinical Practice, 2004)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCN(C)C(=N)N=C(N)N.COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3.Cl
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InChIKeyHCEQQASHRRPQFE-UHFFFAOYSA-N
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Synthesis
5-chloro-2-methoxybenzamide
+
Reactant
(Alkylation of primary amines)
Reactant
+
CYCLOHEXYLAMINE
(Thiourea)
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