| Weight | 295.338 g/mol |
|---|---|
| Formula | C18H17NO3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 0 |
Pukateine (81-67-4)
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SMILESCN1CCC2=CC3=C(C4=C2C1CC5=C4C(=CC=C5)O)OCO3
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Pukateine is an alkaloid found in the bark of the New Zealand tree Laurelia novae-zelandiae ("Pukatea"). An extract from pukatea is used in traditional Mori herbal medicine as an analgesic, and it is thought pukateine is the active component, as it is similar in both structure and activity to alkaloids such as glaucine and tetrahydropalmatine which are found in Chinese medicinal herbs used as analgesics. Pukateine has multiple mechanisms of action, with the most prominent effects being as an agonist at the D2 dopamine receptor and antagonist at the 1-adrenergic receptor.
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